Brownsville (/ˈbraʊnzˌvɪl/) is a city in Cameron County in the U.S. state of Texas. It is on the western Gulf Coast in South Texas, adjacent to the border with Matamoros, Mexico. The city covers 145.2 sq mi (376.066 km2), and has an estimated population of 182,781 as of 2019. It is the 131st-largest city in the United States and 18th-largest in Texas. It is part of the Matamoros–Brownsville metropolitan area. The city is known for its year-round subtropical climate, deep-water seaport, and Hispanic culture.

The city was founded in 1848 by American entrepreneur Charles Stillman after he developed a successful river-boat company nearby. It was named for Fort Brown, itself named after Major Jacob Brown, who fought and died while serving as a U.S. Army soldier during the Mexican–American War (1846–48).